It is has been shown that the majority of T. cruzi strains isolated from Mexico belong to the T. cruzi I (TCI). The immune response produced in response to Mexican T. cruzi I strains has not been well characterized. In this study, two Mexican T. cruzi I strains were used to infect Balb/c mice. The Queretaro (TBAR/MX/0000/Queretaro)(Qro) strain resulted in 100% mortality. In contrast, no mortality was observed in mice infected with the Ninoa (MHOM/MX/1994/Ninoa) strain. Both strains produced extended lymphocyte infiltrates in cardiac tissue. Ninoa infection induced a diverse humoral response with a higher variety of immunoglobulin isotypes than were found in Qro-infected mice. Also, a stronger inflammatory TH1 response, represented by IL-12p40, IFNγ, RANTES, MIG, MIP-1β, and MCP-1 production was observed in Qro-infectedmice when compared with Ninoainfected mice.We propose that an exacerbated TH1 immune response is a likely cause of pathological damage observed in cardiac tissue and the primary cause of death in Qro-infected mice. © 2010 B. Espinoza et al.
CITATION STYLE
Espinoza, B., Rico, T., Sosa, S., Oaxaca, E., Vizcaino-Castillo, A., Caballero, M. L., & Martínez, I. (2010). Mexican Trypanosoma cruzi T. cruzi i strains with different degrees of virulence induce diverse humoral and cellular immune responses in a murine experimental infection model. Journal of Biomedicine and Biotechnology, 2010. https://doi.org/10.1155/2010/890672
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