Clear cell renal cell carcinoma (ccRCC), the most frequent subtype of renal cell cancer, is characterized by mutation of the von Hippel-Lindau (VHL) tumor suppressor gene, which results in stabilization of hypoxia-inducible factor (HIF) a proteins. In this issue of Cancer Discovery, Mathew and colleagues report that miR-30c-2-3p and miR-30a-3p downregulation in ccRCC promotes increased expression of HIF2α. © 2014 AACR.
CITATION STYLE
Moch, H., & Lukamowicz-Rajska, M. (2014). miR-30c-2-3p and mir-30a-3p: New pieces of the jigsaw puzzle in HIF2α regulation. Cancer Discovery, 4(1), 22–24. https://doi.org/10.1158/2159-8290.CD-13-0897
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