Mixed-lineage kinase control of JNK and p38 MAPK pathways.
Nature Reviews Molecular Cell Biology (2002)
- PubMed: 12209126
Available from www.ncbi.nlm.nih.gov
or
Abstract
Mixed-lineage kinases (MLKs) are serine/threonine protein kinases that regulate signalling by the c-Jun amino-terminal kinase (JNK) and p38 mitogen-activated-protein kinase (MAPK) pathways. MLKs are represented in the genomes of both Caenorhabditis elegans and Drosophila melanogaster. The Drosophila MLK Slipper regulates JNK to control dorsal closure during embryonic morphogenesis. In mammalian cells, MLKs are implicated in the control of apoptosis and are potential drug targets for many neurodegenerative diseases.
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Available from www.ncbi.nlm.nih.gov
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