Objective: The aim of this study was to investigate the contribution of 6 polymorphic variants of the MSX1 gene in non-syndromic cleft lip and/or palate (NSCL/P). Methods: Three hundred and fifty-eight individuals (158 NSCL/P cases and 200 controls) were genotyped by TaqMan allelic discrimination using predesigned SNP assays. Statistical analyses were conducted using the software SPSS 15.0 and the R statistical suite. Haplotype block structure and haplotype frequencies were determined using the Haploview. A P-value of 0.05 and confidence interval of 95% were used for all of statistical tests. Results: The patients with non-syndromic cleft lip and/or palate were characterized by similar distribution of MSX1 genotypes and allele in comparison to subjects without oral clefts (P > 0.05). Two haplotype blocks were constructed with polymorphisms of MSX1 gene and haplotypes formed showed a similar frequency in patients with and without oral clefts. CONCLUSIONS: The present study provides no evidence that MSX1 polymorphisms (rs3775261, rs1042484, rs12532, rs6446693, rs4464513 and rs1907998) play a major role in NSCL/P. © 2012 John Wiley & Sons A/S.
CITATION STYLE
Cardoso, M. L., Bezerra, J. F., Oliveira, G. H. M., Soares, C. D., Oliveira, S. R., de Souza, K. S. C., … Rezende, A. A. (2013). MSX1 gene polymorphisms in non-syndromic cleft lip and/or palate. Oral Diseases, 19(5), 507–512. https://doi.org/10.1111/odi.12033
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