Polymorphisms in the microsomal triglyceride transfer protein (MTTP) gene were genotyped in individuals who were chronically infected with hepatitis C virus (HCV). In the 236 patients, the frequencies of risk alleles of the -164T/C (rs1800804), -400A/T (rs1800803) and H297Q (rs2306985) polymorphisms were 0.30, 0.41 and 0.50, respectively. A significant association between the risk alleles of the -164T/C and -400A/T polymorphisms combined with HCV genotype 3 infection and the occurrence of steatosis was detected (p = 0.004 and p = 0.032), suggesting that a combination of host and viral factors can potentially be used to predict hepatic steatosis.
CITATION STYLE
Prata, T. V. G., Silva, D. de S. R. da, Manchiero, C., Dantas, B. P., Mazza, C. C., Nunes, A. K. da S., … Magri, M. C. (2019). MTTP polymorphisms and hepatic steatosis in individuals chronically infected with hepatitis C virus. Archives of Virology, 164(10), 2559–2563. https://doi.org/10.1007/s00705-019-04352-4
Mendeley helps you to discover research relevant for your work.