Neurological regeneration

Abstract

6.4 Mechanisms of€Action of€Mesenchymal Stromal Cell-ƯBased \Therapies in€Animal Models of€Neonatal Hypoxia-Ischemia. Includes index. This invaluable resource explores the regenerative potential of stem cells in the nervous system, with a focus on clinical applications. The expertly authored chapters discuss cell-based therapies for spinal cord injury and regeneration, traumatic brain injury, glioblastoma, Parkinson's Disease, ischemic stroke, cell banking, human embryonic stem cells and related concerns, harvesting of adipose tissue, and more. These topics are contextualized within a discussion of future directions of these therapies. Neurological Regeneration, part of Springerℓ́ℓs Stem Cells in Clinical Applications series, is essential reading for scientists, researchers, advanced students and clinicians working in stem cells, neurology, regenerative medicine or tissue engineering. Preface; Contents; Biography; Chapter 1: Stem Cell Therapy in€Neurological and€Neurodegenerative Disease; 1.1 Introduction; 1.2 Types of€Stem Cells; 1.2.1 Embryonic Stem Cells; 1.2.2 Induced Pluripotent Stem Cells; 1.2.3 Tissue-Specific Stem Cells; 1.3 Stem Cell Therapy for€Neurological Diseases; 1.3.1 Alzheimer's Disease; 1.3.2 Parkinson's Disease; 1.3.3 Huntington's Disease; 1.3.4 Cancer; 1.4 Conclusion; References; Chapter 2: Stem Cell Therapy in€Traumatic Brain Injury; 2.1 Introduction; 2.2 Neuropathology of€Traumatic Brain Injury; 2.2.1 Primary Injury After Traumatic Brain Injury. 2.2.2 Secondary Injury After Traumatic Brain Injury2.3 Current Pharmacotherapy for€Traumatic Brain Injury; 2.4 Stem Cell Therapy in€Traumatic Brain Injury; 2.4.1 Transplantation of€Exogenous Stem Cells in€Traumatic Brain Injury; 2.4.2 Stimulation of€Endogenous Neural Precursor Cells in€Traumatic Brain Injury; 2.5 Bench to€Bedside Translation of€Stem Cell Therapy in€Traumatic Brain Injury; 2.6 Conclusion; References; Chapter 3: Stem Cells in€Alzheimer's Disease Therapy; 3.1 Introduction; 3.2 Pathogenesis of€Alzheimer's Disease and€Drug Treatment; 3.3 Animal Models in€AD Therapy with€Stem Cells. 3.4 Stem Cells as€a€Model to€Study AD3.5 The Use of€Stem Cells in€AD Therapy; 3.6 Conclusion; References; Chapter 4: Stem Cell-Based Approaches for€Treatment of€Glioblastoma; 4.1 Introduction; 4.2 Glioblastoma; 4.2.1 Epidemiology; 4.2.2 Genetic Background; 4.3 Current Treatment Options for€Glioblastoma; 4.3.1 Standard of€Care; 4.3.2 Molecular Treatment Strategies; 4.3.3 Limitations of€Available Treatments; 4.4 Application of€Stem Cells to€Glioblastoma Therapy; 4.4.1 Rationale for€Stem Cell-Based Therapies; 4.4.2 Application of€Stem Cells for€Treatment of€Glioblastoma; 4.4.3 Immunotoxins. 4.4.4 Suicide Gene Fusion4.4.5 Oncolytic Viruses; 4.4.6 miRNAs; 4.5 Future Directions; 4.5.1 Limitations and€Potential Solutions; 4.5.2 Ethical Concerns; 4.5.3 Concluding Remarks; References; Chapter 5: Stem Cell-Based Therapies for€Parkinson's Disease; 5.1 Introduction; 5.2 Grafts of€Human Fetal Ventral Mesencephalic Tissue; 5.3 Stem Cell Properties and€Requirements for€Their Application in€CRT for€PD; 5.4 Multipotent Stem Cells; 5.4.1 Human Neural Stem Cells; 5.4.2 Human Mesenchymal Stem Cells; 5.4.3 Human Pluripotent Stem Cells; 5.4.4 Human Embryonic Stem Cells. 5.4.5 Human Parthenogenetic Embryonic Stem Cells5.4.6 Human Induced Pluripotent Stem Cells; 5.5 Conclusions and€Future Directions; References; Chapter 6: Mesenchymal Stromal Cell Therapy for€Neonatal Hypoxic-Ischemic Encephalopathy; 6.1 Introduction; 6.2 Mesenchymal Stromal Cells; 6.3 The Therapeutic Efficacy of€Mesenchymal Stromal Cells in€Preclinical Animal Models of€Neonatal Hypoxia-Ischemia; 6.3.1 Mesenchymal Stromal Cells from€Adult Tissues; 6.3.2 Mesenchymal Stromal Cells from€Neonatal Tissues.