The saline leaf extract of Bryophyllum pinnatum was investigated on neuropharmacological activities to ascertain claims of local use. When tested in mice, it produced a dose-dependent prolongation of onset and duration of pentobarbitone-induced hypnosis, reduction of exploratory activities in the head-dip and evasion tests. Moreover, a dose-dependent muscle in-coordination was observed in the inclined screen, traction and climbing tests. It delayed onset to convulsion in both strychnine- and picrotoxin-induced seizures in addition to minimal protection against picrotoxin seizures. © 2005 Elsevier B.V. All rights reserved.
CITATION STYLE
Yemitan, O. K., & Salahdeen, H. M. (2005). Neurosedative and muscle relaxant activities of aqueous extract of Bryophyllum pinnatum. Fitoterapia, 76(2), 187–193. https://doi.org/10.1016/j.fitote.2004.11.009
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