New bioactive diterpene polyesters from Euphorbia decipiens

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Abstract

A reinvestigation with a modified extraction procedure of Euphorbia decipiens resulted in the isolation and structure elucidation of three new myrsinane-type diterpene esters (1-3). The structures of compounds 1-3 were elucidated by spectroscopic data interpretation. Compound 1 showed inhibitory activity against prolyl endopeptidase (PEP), whereas compound 2 exhibited DNA-damaging activity in a mutant yeast bioassay.

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Ahmad, V. U., Hussain, H., Jassbi, A. R., Hussain, J., Bukhari, I. A., Yasin, A., … Choudhary, M. I. (2003). New bioactive diterpene polyesters from Euphorbia decipiens. Journal of Natural Products, 66(9), 1221–1224. https://doi.org/10.1021/np020186a

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