A new indicator of human malignant tumour

Abstract

In haemagglutination tests we have found that the monoclonal antibody B5 discriminates between erythrocytes from patients with malignant cancer (total 386; > 80% B5 positive) and individuals with no known tumour (total 247; < 20% B5 positive). The B5 antigen detected on intact erythrocytes is a tightly bound surface component which does not appear to be derived from the plasma. The B5 antigen is not T, Tn, Ca1, CEA or the Forsmann antigen, nor is it related to any of the major blood group antigens. Abnormal levels of surface B5 are found on erythrocytes from patients with a great diversity of tumours and this fact presents B5 as an indirect marker of malignancy. Successful eradication of tumour is associated with a switch from positive to negative B5 haemagglutination. We believe that B5 is a valuable addition to the few useful tumour markers already employed for monitoring tumour status. © 1984 The Macmillan Press Ltd.