New strategy of controlled, stepwise release from novel MBioF and its potential application for drug delivery systems

Abstract

Metal organic structures have gained recently an interest in many fields. Among them, metal–biomolecule framework materials with amino acids applied as organic linkers have attracted the growing attention. An application of tailored metal–biomolecule frameworks, easily decomposing in an acidic and/or reductive environment in a steerable way, is reported here. From these biocompatible, non-porous, and nanostructured drug carrier systems, the desirable portion of drug could be released depending on the portion of acid, i.e. immediately and/or in a multi-step process due to a structure decomposition. The application of naturally occurring elements as cystine ensures full biocompatibility of the obtained system as well as its degradation products. Presented materials offer potential application in drug delivery systems.