A novel galectin-1 and interleukin 2 receptor β haplotype is associated with autoimmune myasthenia gravis

20Citations
Citations of this article
28Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Galectin-1 (LGALS1) and interleukin receptor 2β (IL2Rβ) are regulators of T-cell activation. Here we evaluated the association of regulatory region polymorphisms of the LGALS1 (rs4820293, rs4820294) and IL2Rβ (rs743777, rs228941) genes in 146 Caucasian myasthenia gravis patients compared to 291 ethnically matched controls. A significant difference was found in the distribution of the rs4820293/rs743777 polymorphism haplotypes (p<0.01). The rs4820293 polymorphism, previously not described to be associated with any disease, does not affect LGALS1 expression in peripheral mononuclear cells and skeletal muscle. Pathway analysis revealed interaction between LGALS1 and IL2Rβ suggesting a role of these proteins in this rare disease. © 2010 Elsevier B.V.

Author supplied keywords

Cite

CITATION STYLE

APA

Pál, Z., Antal, P., Millinghoffer, A., Hullám, G., Pálóczi, K., Tóth, S., … Buzás, E. I. (2010). A novel galectin-1 and interleukin 2 receptor β haplotype is associated with autoimmune myasthenia gravis. Journal of Neuroimmunology, 229(1–2), 107–111. https://doi.org/10.1016/j.jneuroim.2010.07.015

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free