Oestrogen receptor polymorphisms and late-life depression

35Citations
Citations of this article
49Readers
Mendeley users who have this article in their library.

Abstract

Background: Evidence suggests a role for oestrogen in depression but the involvement of oestrogen receptor polymorphisms remains unknown. Aims: To determine the association between oestrogen receptor polymorphisms and late-life depression and the modifying effect of hormone treatment. Method: Depression was assessed using the Mini-International Neuropsychiatric Interview, according to DSM-IV criteria and the Centre for Epidemiologic Studies - Depression Scale. The association between oestrogen receptor α and β (ER-α and ER-β) polymorphisms with severe depression was examined in 6017 community-dwelling elderly people using multivariate logistic regression. Results: In women, the ER-α rs2234693 and rs9340799 polymorphisms were significantly associated with the risk of late-life depression. The A allele of ER-β rs1256049 increased the risk of depression, but only for non-current users of hormone treatment. In men, only the ER-β rs4986938 polymorphism showed a weak association with depression risk. Conclusions: Oestrogen receptor polymorphisms are associated with severe late-life depression risk in women only.

Cite

CITATION STYLE

APA

Ryan, J., Scali, J., Carrière, I., Peres, K., Rouaud, O., Scarabin, P. Y., … Ancelin, M. L. (2011). Oestrogen receptor polymorphisms and late-life depression. British Journal of Psychiatry, 199(2), 126–131. https://doi.org/10.1192/bjp.bp.111.091751

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free