Previous studies implicated centrosomal dysfunction as a source of various neuropsychiatric disorders, including schizophrenia (SZ). Two recent reports [Gurling et al., 2006; Datta et al., 2008. Mol Psychiatry] described an association between polymorphisms in the PCM1 gene and SZ in a UK/Scottish population. In this study, we aimed to replicate these findings in a Northern Swedish association sample of 486 research subjects with SZ and 512 unrelated control individuals. We genotyped 12 previously described SNPmarkers and carried out haplotype analyses using the same multi-marker haplotypes previously reported. Though we could not replicate the association with SNPs rs445422 and rs208747, we did observe a significant protective association with intronic SNP rs13276297. Furthermore, we performed a meta-analysis comprising 1,794 SZ patients and 1,553 controls, which confirmed the previously reported association with rs445422 and rs208747. These data provide further evidence that PCM1 - though certainly not a major risk factor in the Northern Swedish population - cannot be ruled out as a contributor to SZ risk and/or protection, and deserves further replication in larger populations to elucidate its role in disease etiology. © 2010 Wiley-Liss, Inc.
CITATION STYLE
Moens, L. N., Ceulemans, S., Alaerts, M., Van Den Bossche, M. J. A., Lenaerts, A. S., De Zutter, S., … Del-Favero, J. (2010). PCM1 and schizophrenia: A replication study in the northern Swedish population. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 153(6), 1240–1243. https://doi.org/10.1002/ajmg.b.31088
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