Persistent generalized lymphadenopathy (PGL) mimicking lymphoma on whole-body FDG PET/CT imaging

Abstract

We present PET/CT images of a 42-year-old HIV-positive man who presented with generalized lymphadenopathy and systemic symptoms suggestive of lymphoma. Whole-body PET/CT revealed hypermetabolic lymphadenopathy bilaterally in the neck, axilla, and inguinal regions, and hypermetabolism in an enlarged spleen. These findings were thought to be typical for lymphoma. The biopsy of right axillary lymph nodes showed no evidence of lymphoma but findings characteristic of persistent generalized lymphadenopathy (PGL). Copyright © 2006 by Lippincott Williams & Wilkins.