The pharmacokinetics and bioavailability of hydrocortisone after rectal administration of a hydrocortisone acetate foam was determined. Endogenous hydrocortisone was suppressed by dexamethasone administration. Plasma levels were compared with those observed after iv and oral administration. Only a very small part of the rectal dose (100 mg) was absorbed; the mean absolute bioavailability was 2%. There was substantial intersubject variability. Maximum hydrocortisone levels were reached after 2 h and averaged 35 ng/mL. These levels were 10‐fold lower than those obtained after oral administration of a fivefold lower dose (20 mg) of hydrocortisone in the same subjects. Copyright © 1991 Wiley‐Liss, Inc., A Wiley Company
CITATION STYLE
Möllmann, H., Barth, J., Möllmann, C., Tunn, S., Krieg, M., & Derendorf, H. (1991). Pharmacokinetics and rectal bioavailability of hydrocortisone acetate. Journal of Pharmaceutical Sciences, 80(9), 835–836. https://doi.org/10.1002/jps.2600800906
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