Phenylarsine oxide and denervation effects on hormone-stimulated glucose transport

25Citations
Citations of this article
N/AReaders
Mendeley users who have this article in their library.
Get full text

Abstract

Insulin and insulin-like growth factor I (IGF-I) stimulate glucose transport in skeletal muscle through separate receptors. The proximal postreceptor events in coupling insulin and IGF-I receptors to glucose transport have been suggested to differ. Denervation of skeletal muscle produces a postreceptor insulin resistance presumably at an early step in the signaling cascade. We examined the effects of denervation and phenylarsine oxide (PAO), an agent believed to block insulin action on transport at a postreceptor step, on insulin and IGF-I stimulated 2-deoxy-D-glucose transport in isolated solei. Denervation (24 h) produced severe IGF-I resistance without affecting IGF-I receptor number of affinity. PAO inhibited insulin and IGF-I stimulation of transport in control muscles by ~90 and ~70%, respectively. In denervated muscle PAO inhibited transport stimulation by both hormones less than in controls. Conclusions are that 1) skeletal muscle insulin and IGF-I receptors signal transport mainly through a PAO-sensitive mechanism, but IGF-I's action involves a larger PAO-resistant component; 2) the denervation-induced postreceptor resistance of glucose transport to both hormones involves primarily the PAO-sensitive pathway.

Cite

CITATION STYLE

APA

Sowell, M. O., Robinson, K. A., & Buse, M. G. (1988). Phenylarsine oxide and denervation effects on hormone-stimulated glucose transport. American Journal of Physiology - Endocrinology and Metabolism, 255(2). https://doi.org/10.1152/ajpendo.1988.255.2.e159

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free