Objective: Based on a small sample of cases with schizophrenia and control individuals from an isolated population, a genome-wide association study was undertaken to find variants conferring susceptibility to this disease. Methods: Standard association tests were employed, followed by newer multilocus association methods (genotype patterns). Results: Individually, no variant produced a significant result. However, the best two variants (rs1360382 on chromosome 9 and rs1303 on chromosome 14) showed significantly different genotype pattern distributions between patients and control individuals. The risk genotype pattern AA-TT is highly predictive of schizophrenia, with estimated sensitivity and specificity of 1 and 0.96, respectively. Conclusions: These findings support the hypothesis that schizophrenia is partly due to multiple genetic variants, each with a relatively small effect. Copyright © 2010 S. Karger AG.
CITATION STYLE
Ott, J., MacCiardi, F., Shen, Y., Carta, M. G., Murru, A., Triunfo, R., … Siniscalco, M. (2010). Pilot study on schizophrenia in Sardinia. Human Heredity, 70(2), 92–96. https://doi.org/10.1159/000313844
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