Plasma lipid and lipoprotein concentrations in symptomatic postpolio patients

Abstract

This study reports lipid and lipoprotein concentrations in postpolio patients seen in our postpolio clinic who were evaluated for complaints of progressive weakness, fatigue, and/or pain. Concentrations of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) were determined after an overnight fast. Sixty-four patients (24 men and 40 women) with a mean age of 48 ± 10 years were studied. Mean (± SD) lipid concentrations (mg/dL) for men and women, respectively, were 220 ± 46 and 213 ± 43 for TC; 38.5 ± 8.6 and 59.1 ± 18.1 for HDL-C; 148 ± 46 and 129 ± 36 for LDL-C; and 205 ± 107 and 105 ± 55 for TG. Hyperlipidemia was found in 16 of 24 men and 10 of 40 women. In the men, mean HDL-C concentration was in the lowest decile of our hospital laboratory's reference range, whereas mean TC/HDL-C ratio was elevated above the recommended value. It is suggested that lipid and lipoprotein concentrations be evaluated in postpolio patients because a high prevalence of lipid/lipoprotein disorders was found in our subjects. Further research is needed on this topic.