Polymorphisms of OCT2, GGT1, HO1, and DNASE1 genes and nephrotoxicity of cysplatin in ovarian cancer patients

Abstract

DNA polymorphism is an important factor in the interindividual variations in the reactions of patients to the same drugs. In the current study, the polymorphism in the OCT2, GGT1, HO1, and DNASE1 genes were evaluated for the correlation with cisplatin nephrotoxicity in ovarian cancer patients. An increased risk of nephrotoxicity (OR = 2.19, 95% CI 0.953-5.038 p = 0.088) was noted for patients with the homozy- gous GGT1 T/T genotype (rs5751901). An analysis of associations between polymorphisms of the studied genes and other side effects of the used chemotherapy regimens revealed the pronounced correlation between thrombocytopenia and DNASE1 G/A polymorphism (rs1053874) (Φ2 = 6.49; p = 0.039).© Allerton Press, Inc., 2010.