Background: Several studies have demonstrated a link between cardiovascular disease (CVD) susceptibility and the genetic background of populations. Endothelial activation and dysfunction induced by oxidized low-density lipoprotein (ox-LDL) is one of the key steps in the initiation of atherosclerosis. The oxidized low density lipoprotein (lectin-like) receptor 1 (OLR1) gene is the main receptor of ox-LDL. We have previously characterized two polymorphisms (rs3736235 and rs11053646) associated with the risk for coronary artery disease (CAD) and acute myocardial infarction (AMI). Aim: Given their clinical significance, it is of interest to know the distribution of these variants in populations from different continents. Subjects and methods: A total of 1229 individuals from 17 different African, Asian and European populations was genotyped for the two considered markers. Results: The high frequencies of ancestral alleles in South-Saharan populations is concordant with the African origin of our species. The results highlight that African populations are closer to Asians, and clearly separated from the Europeans. Conclusion: The results confirm significant genetic structuring among populations and suggest a possible basis for varying susceptibility to CVD among groups correlated with the geographical location of populations linked with the migrations out of Africa, or with different lifestyle. © 2010 Informa UK Ltd.
CITATION STYLE
Predazzi, I. M., Martínez-Labarga, C., Vecchione, L., Mango, R., Ciccacci, C., Amati, F., … Novelli, G. (2010). Population differences in allele frequencies at the OLR1 locus may suggest geographic disparities in cardiovascular risk events. Annals of Human Biology, 37(2), 137–149. https://doi.org/10.3109/03014460903393857
Mendeley helps you to discover research relevant for your work.