A collection of clinical (n 47) and environmental (n 79) Fusarium isolates were tested against 10 antifungal drugs, including 2 novel imidazoles. Luliconazole and lanoconazole demonstrated very low geometric mean MIC values of 0.005 and 0.013 g/ml, respectively, compared with 0.51 g/ml for micafungin, 0.85 g/ml for efinaconazole, 1.12 g/ml for natamycin, 1.18 g/ml for anidulafungin, 1.31 g/ml for voriconazole, 1.35 g/ml for caspofungin, 1.9 g/ml for amphotericin B, and 4.08 g/ml for itraconazole. Results show that these drugs are potential candidates for (topical) treatment of skin and nail infections due to Fusarium species.
CITATION STYLE
Abastabar, M., Al-Hatmi, A. M. S., Moghaddam, M. V., De Hoog, G. S., Haghani, I., Aghili, S. R., … Badalia, H. (2018). Potent Activities of Luliconazole, Lanoconazole, and Eight Comparators against Molecularly Characterized Fusarium Species. Antimicrobial Agents and Chemotherapy, 62(5). https://doi.org/10.1128/AAC.00009-18
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