Pre-exercise high-fat diet for 3 days affects post-exercise skeletal muscle glycogen repletion

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Abstract

Previous studies have shown that the short-term intake of a high-fat diet (HFD) impairs glucose metabolism. In this study, we investigated the influences of pre-exercise HFD intake for 3 d on post-exercise glycogen repletion in skeletal muscle in ICR mice. Mice received either an HFD (57% kcal from fat, 23% kcal from carbohydrate; HFD group) or standard laboratory chow (13% kcal from fat, 60% kcal from carbohydrate; Con group) for 3 d before exercise. Mice performed treadmill running at 25 m/min for 60 min and were orally administered a glucose (2 mg/g body weight) solution immediately after and at 60 min after exercise. A negative main effect of pre-exercise HFD intake was observed for skeletal muscle glycogen concentration from the pre-exercise phase to 120 min of post-exercise recovery (p,0.01). Blood glucose concentration in the HFD group was significantly higher than in the Con group at 120 min after exercise (p,0.01). No significant difference was observed in plasma insulin concentration. There were no significant between-group differences in the phosphorylation state of Akt Thr308, AMPK Thr172, AS160 Thr642, or glycogen synthase Ser641 or in glucose transporter 4 protein levels during post-exercise recovery. Our results suggest that the intake of a pre-exercise HFD for 3 d affects post-exercise glycogen repletion in skeletal muscle without impairing the insulin signaling cascade.

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APA

Takahashi, Y., Matsunaga, Y., Tamura, Y., Terada, S., & Hatta, H. (2017). Pre-exercise high-fat diet for 3 days affects post-exercise skeletal muscle glycogen repletion. Journal of Nutritional Science and Vitaminology, 63(5), 323–330. https://doi.org/10.3177/jnsv.63.323

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