The aim of the present study as to investigate the association of PLIN1 11482G>A (rs894160) and PLIN1 13041A>G (rs2304795) polymorphisms ith body composition, energy and substrate metabolism, and the metabolic response to a 12-eek energy-restricted diet in obese omen. The study comprised a total of seventy-eight obese (BMI 34•0 (sd 2•8) kg/m2) omen (age 36•7 (sd 7) years). e measured eight, height and aist circumference before and after a 12-eek controlled energy-restricted diet intervention. Body fat mass and lean mass ere measured by dual-energy X-ray absorptiometry. RMR and lipid oxidation rate ere measured by indirect calorimetry. We also analysed fasting plasma glucose, insulin, cholesterol and leptin. Women carrying the 11482A allele had a lower reduction in waist circumference than non-A allele carriers (3•2 (sd 0•5) v. 4•6 (sd 0•6) %, respectively, P = 0•047; P for gene diet interaction = 0•064). Moreover, women with the 11482A allele had a higher decrease in lipid oxidation rate than non-A allele carriers (58•9 (sd 6•7) v. 31•3 (sd 8•2) %, respectively, P = 0•012; P for genediet interaction = 0•004). There was no interaction effect between the 13041A>G polymorphism and diet-induced changes on the outcome variables (all P>0•1). These results confirm and extend previous findings suggesting that the PLIN1 11482G>A polymorphism plays a modulating role on diet-induced changes in body fat and energy metabolism in obese women. © 2011 The Authors.
CITATION STYLE
Ruiz, J. R., Larrarte, E., Margareto, J., Ares, R., Alkorta, P., & Labayen, I. (2011). Preliminary findings on the role of PLIN1 polymorphisms on body composition and energy metabolism response to energy restriction in obese omen. British Journal of Nutrition, 106(4), 486–490. https://doi.org/10.1017/S0007114511000432
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