The neonatal T-cell system is capable of responding to allergens at birth, indicating the occurrence of prenatal sensitization, and the cytokine profile of these responses is skewed towards the Th-2 type. This response is further modified by postnatal exposure to different types of allergens. In relation to inhalant allergen (employed by HDM) the low level fetal Th-2 responses in non-atopics appear to be down-regulated rapidly after birth, parallel to an increase in allergen-specific IFN-γ production. In contrast, atopics appear to consolidate their initial Th-2 responses, and around the age of 6 exhibit a cytokine response profile similar to the adult pattern. A pre-existing deficiency in IFN-γ production may be one of the key factors determining the postnatal persistence of Th-2 responses in atopics. (C) Munksgaard 2000.
CITATION STYLE
Macaubas, C., Prescott, S. L., Venaille, T. J., Holt, B. J., Smallacombe, T. B., Sly, P. D., & Holt, P. G. (2000). Primary sensitization to inhalant allergens. Pediatric Allergy and Immunology, Supplement, 11(13), 9–11. https://doi.org/10.1034/j.1399-3038.2000.00502.x
Mendeley helps you to discover research relevant for your work.