Sign up & Download
Sign in

Principles of root bark of Hippocratea excelsa (Hippocrataceae) with gastroprotective activity

by Andrés Navarrete, José Luis Trejo-Miranda, Lino Reyes-Trejo
Journal of Ethnopharmacology ()

Abstract

The aqueous and ethanol extracts of the root bark of Hippocratea excelsa HBK. Locally known as 'Cancerina', showed an important gastroprotective effect in several experimental ulcer models in rats. Fractionation of the methanol extract led to four pools of active fractions (F1-F4). Sitosterol-3-O-β-glucoside, β-sitosterol and (-) epicatechin were isolated from the active fractions and showed an important gastroprotective activity (93.4,85.7 and 72.1% of gastroprotection, respectively), whereas bismuth subsalicylate, used as positive control, showed 46.2% of gastroprotection. A mixture of α-amyrin and β-amyrin showed 50% of gastroprotection. Friedelin, canophyllal and canophyllol were isolated from the active fractions, but they were inactive as gastroprotective compounds. These results provide additional support for the popular use of this plant as an antiulcer remedy in the Mexican traditional medicine. © 2002 Elsevier Science Ireland Ltd. All rights reserved.

Cite this document (BETA)

Readership Statistics

5 Readers on Mendeley
by Discipline
 
 
 
by Academic Status
 
60% Ph.D. Student
 
20% Student (Master)
 
20% Associate Professor

Sign up today - FREE

Mendeley saves you time finding and organizing research. Learn more

  • All your research in one place
  • Add and import papers easily
  • Access it anywhere, anytime

Start using Mendeley in seconds!

Already have an account? Sign in