Psychopharmacological evaluation of ethanolic extract of leaves of bauhinia tomentosa L. In mice

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Abstract

Aim: The present study was designed to investigate the effects of ethanolic extract of leaves of Bauhinia tomentosa L (EEBT) in several Psychopharmacological experimental models. Methods: Swiss albino mice of either sex, weighing about 20-25 gm were used. Anxiolytic activity was done by elevated plus maze model, Hole board test and Light dark model. Antidepressant activity was done using Actophotometer (locomotor activity), forced swim test, Diazepam induced sleeping time in mice. Nootropic activity using elevated plus maze model, Motor coordination activity using Rota rod test and Catatonic activity by Haloperidol induced catalepsy were done. Results: The extract at doses (200 and 400 mg/Kg, p.o.) revealed the anti-anxiety activity. The depressant activity was confirmed by spontaneous locomotor activity and forced swim test at the dose levels of (200 and 400 mg/Kg, p.o.), and diazepam-induced sleeping time in mice at the dose of 200 mg/Kg, p.o. In dose of 400 mg/Kg, p.o., the extract significantly increased the inflexion ratio, which confirmed its nootropic activity. The extract (200 and 400 mg/Kg, p.o.) has shown no significant effect on motor co-ordination and potentiated the catalepsy at 30 min. after haloperidol administration at (200 mg/Kg, p.o.). Conclusion: The results of the present work suggested that the EEBT has an anxiolytic and Central nervous system(CNS) depressant activity with mild antipsychotic activity which may be due to the presence of flavonoids as its important phyto constituent, exhibiting its action through GABA A receptors in CNS.

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Sathya, B., Ariharasivakumar, G., Vimalson, D. C., Subramani, M., & Magesh, M. (2011). Psychopharmacological evaluation of ethanolic extract of leaves of bauhinia tomentosa L. In mice. International Journal of Pharmacy and Technology, 3(4), 3693–3709.

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