The authors propose a novel noninvasive therapeutic approach for degenerative calcified bioprosthetic heart valves based on pulsed cavitational ultrasound (PCU) to improve the valvular function by remotely softening calcified stiff cusps. This study aims to demonstrate both in vivo, using an ovine model with implanted human calcified bioprosthesis, and in vitro that PCU can significantly improve the bioprosthesis function. A 50% decrease of the transvalvular gradient was found, demonstrating a strong improvement of the valve opening function. This new noninvasive approach has the potential to improve the outcomes of patients with severe bioprosthesis stenosis.
CITATION STYLE
Villemain, O., Robin, J., Bel, A., Kwiecinski, W., Bruneval, P., Arnal, B., … Pernot, M. (2017). Pulsed Cavitational Ultrasound Softening: A New Noninvasive Therapeutic Approach for Calcified Bioprosthetic Valve Stenosis. JACC: Basic to Translational Science, 2(4), 372–383. https://doi.org/10.1016/j.jacbts.2017.03.012
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