Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium.

Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium.

by Xuri Li, Marc Tjwa, Inge Van Hove, Berndt Enholm, Elke Neven, … Karri Paavonen, Michael Jeltsch, Toni Diez Juan, Richard E Sievers, Emmanuel Chorianopoulos, Hiromichi Wada, Maarten Vanwildemeersch, Agnes Noel, Jean-Michel Foidart, Matthew L Springer, Georges Von Degenfeld, Mieke Dewerchin, Helen M Blau, Kari Alitalo, Ulf Eriksson, Peter Carmeliet, Lieve Moons show all authors

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Arteriosclerosis thrombosis and vascular biology (2008)

Volume: 28, Issue: 9, Pages: 1614-1620

PubMed: 18511699

Available from Michael Jeltsch's profile on Mendeley.

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Abstract

OBJECTIVE: The endogenous role of the VEGF family member vascular endothelial growth factor-B (VEGF-B) in pathological angiogenesis remains unclear. METHODS AND RESULTS: We studied the role of VEGF-B in various models of pathological angiogenesis using mice lacking VEGF-B (VEGF-B(-/-)) or overexpressing VEGF-B(167). After occlusion of the left coronary artery, VEGF-B deficiency impaired vessel growth in the ischemic myocardium whereas, in wild-type mice, VEGF-B(167) overexpression enhanced revascularization of the infarct and ischemic border zone. By contrast, VEGF-B deficiency did not affect vessel growth in the wounded skin, hypoxic lung, ischemic retina, or ischemic limb. Moreover, VEGF-B(167) overexpression failed to enhance vascular growth in the skin or ischemic limb. CONCLUSIONS: VEGF-B appears to have a relatively restricted angiogenic activity in the ischemic heart. These insights might offer novel therapeutic opportunities.

Author-supplied keywords

angiogenesis inducing agents angiogenesis inducing agents metabolism animal animals coronary vessels coronary vessels drug effects coronary vessels metabolism coronary vessels physiopathology disease models gene therapy gene therapy methods gene transfer techniques hindlimb inbred c57bl ischemia ischemia metabolism ischemia pathology ischemia physiopathology ischemia therapy knockout lung lung blood supply mice muscle myocardial ischemia myocardial ischemia metabolism myocardial ischemia pathology myocardial ischemia physiopathology myocardial ischemia therapy myocardium myocardium metabolism myocardium pathology neovascularization nude physiologic physiologic drug effects recombinant proteins recombinant proteins metabolism retinal vessels retinal vessels metabolism skeletal skeletal blood supply skin skin blood supply up regulation vascular endothelial growth factor b vascular endothelial growth factor b administrati vascular endothelial growth factor b deficiency vascular endothelial growth factor b genetics vascular endothelial growth factor b metabolism vascular endothelial growth factor receptor 1 vascular endothelial growth factor receptor 1 met

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Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium.

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