{R}elationship between {SNP} of the {IL-18} and susceptibility to pulmonary {TB} in {C}hinese {H}an population

Abstract

{I}nterleukin-18 {(IL-18)} is a multi-functional cytokine capableof inducing either {T}h1 or {T}h2 polarization depending on the immunologicmilieu. {IL-18} may influence the host response to {M}ycobacteriumtuberculosis {(M.tb)} infection. {T}o investigated relationship betweensingle nucleotide {polymorphisms(SNPs)} of the {IL-18} and susceptibilityto pulmonary tuberculosis in {C}hinese {H}an population, we sequencedthe {IL-18} gene to detect polymorphisms and to examine the genotypefrequencies in 300 patients and 702 healthy controls. {DNA} resequencingrevealed three {IL-18} variants: rs1946518, rs5744247, and rs549908,and found allele {A} of rs1946518 had a 1.47-fold increased riskof developing {TB} {(P} = 0.0001, {OR(95%CI)} = 1.47 (1.21-1.78)),and the {C} allele of rs5744247 had a 0.77-fold decreased risk ofdisease {(P} = {0.01,R(95%CI)} = 0.77 (0.632-0.937)), genotype ofrs1946518, rs5744247 and rs549908 were to be significantly associatedwith {TB.} {E}stimation of the frequencies of haplotypes revealeda potential risk haplotype {AGA} (p = 0.01, {OR(95%CI)} = 1.41(1.15-1.72))and a protective haplotype {CCA} (p = 0.01, {OR(95%CI)} = 0.70(0.57-0.85))for {TB.} {O}ur findings suggest that the polymorphisms in {IL-18}gene may affect susceptibility to {TB} and increase risk of developingthe disease in {C}hinese {H}an population.