Research has shown that aging is associated with increased systemic inflammation as well as a reduction in the strength of immune responses. However, little evidence exists linking the decrease in cell-mediated immunity in older adults with other health parameters. We sought to examine the relationship between cell-mediated immunity as measured in vivo by the delayed-type hypersensitivity (DTH) response to candida antigen and demographic and physiological variables in older (65-80 y.o.) adults. Candida antigen response was not related to gender or obesity, or to a number of other physiological variables including fitness and body composition. However, positive responders had significantly lower serum C-reactive protein levels (CRP, p<0.05) vs. non-responders. Furthermore, subjects with CRP<4.75 mg•L-1 had greater odds of developing a positive response compared to those with CRP>4.75 mg•L-1. Therefore, positive responses to candida antigen in older adults appears to be related to lower levels of systemic inflammation. © 2012 Pence et al.
CITATION STYLE
Pence, B. D., Lowder, T. W., Keylock, K. T., Potter, V. J. V., Cook, M. D., McAuley, E., & Woods, J. A. (2012). Relationship between systemic inflammation and delayed-type hypersensitivity response to Candida antigen in older adults. PLoS ONE, 7(5). https://doi.org/10.1371/journal.pone.0036403
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