Remodeling Cildb, a popular database for cilia and links for ciliopathies

Abstract

New generation technologies in cell and molecular biology generate large amountsof data hard to exploit for individual proteins. This is particularly true forciliary and centrosomal research. Cildb is a multi–species knowledgebasegathering high throughput studies, which allows advanced searches to identifyproteins involved in centrosome, basal body or cilia biogenesis, composition andfunction. Combined to localization of genetic diseases on human chromosomes givenby OMIM links, candidate ciliopathy proteins can be compiled through Cildbsearches. Othology between recent versions of the whole proteomes was computed usingInparanoid and ciliary high throughput studies were remapped on these recentversions. Due to constant evolution of the ciliary and centrosomal field, Cildb has beenrecently upgraded twice, with new species whole proteomes and new ciliary studies,and the latter version displays a novel BioMart interface, much more intuitivethan the previous ones. This already popular database is designed now for easier use and is up to date inregard to high throughput ciliary studies.