Replication of prostate cancer risk loci on 8q24, 11q13, 17q12, 19q33, and Xp11 in African Americans

Abstract

BACKGROUND. Prostate cancer (Pca) is a common malignancy that disproportionately affects African American men (AA). Recently there have been several genome-wide association studies (GWAS) implicating new prostate cancer risk loci along chromosomes 2, 3, 6, 7, 8, 10, 11, 12, 17, 19, and X in populations of European ancestry. Given the higher incidence and mortality for AAs, and differences in allele frequencies and haplotype structures between African and European descent populations, it is important to assess the impact of these candidate risk loci in AAs. METHODS. Here we evaluated 20 single nucleotide polymorphisms (SNPs) associated with prostate cancer risk in recent GWAS studies, in AA prostate cancer cases and controls. RESULTS. We replicated five of the SNPs in our AA population, rs10896449 on 11q13.2 (P=0.009), rs2735839 on 19q33.33 region, (P=0.04), rs443076 on chromosome 17q12 (P=0.008), rs5945572 on Xp11.22 (P=0.05), as well as the rare variant specific to west African ancestry, bd11934905 in region 2 of 8q24 (P=1×10-4). CONCLUSIONS. While we were able to replicate a few of the previous GWASSNPs, we were not able to confirm the vast majority of these associations in our AA population. This finding further supports the need to perform GWAS and additional fine mapping in AAs to locate additional susceptibility loci. © 2009 Wiley-Liss, Inc.