A simple, precise, accurate, and validated reverse phase HPLC method has been developed for the simultaneous estimation of aceclofenac and paracetamol in tablet by reverse phase C-18 column (Intersile 4.6 mmx25 cm, 10 μm) using acetonitrile: 50 mM NaH2 PO4 in a ratio of 65:35 (pH adjusted to 3.0 with orthophosphoric acid) as a mobile phase at a flow rate of 1.5 ml/min and detection at 276 nm. The retention time for aceclofenac and paracetamol was found to be 1.58 and 4.01 min respectively, and recoveries from tablet were between 99 and 101%. The method can be used for estimation of combination of these drugs in tablets.
CITATION STYLE
Momin, M., Yeole, P., Puranik, M., & Wadher, S. (2006). Reverse phase HPLC method for determination of aceclofenac and paracetamol in tablet dosage form. Indian Journal of Pharmaceutical Sciences, 68(3), 387–389. https://doi.org/10.4103/0250-474x.26672
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