The role of hydroxyl radicals in the degradation of DNA by ozone

19Citations
Citations of this article
7Readers
Mendeley users who have this article in their library.
Get full text

Abstract

The degradation of the nucleotides dAMP, dGMP, dCMP and dTMP and of calf thymus DNA by ozone was studied. In all cases both base and sugar moiety were degraded. Furthermore, strand breaks were induced in calf thymus DNA. Hydroxyl radicals were probably involved in the oxidation of the base in dAMP and of the deoxyribose ring, but not in the degradation of the other bases. This indicates that ozone-induced DNA damage proceeds both directly via ozone molecules and indirectly via hydroxyl radicals. © 1987 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

Cite

CITATION STYLE

APA

Van Der Zee, J., Dubbelman, T. M. A. R., & Steveninck, J. V. (1987). The role of hydroxyl radicals in the degradation of DNA by ozone. Free Radical Research, 2(4–6), 279–284. https://doi.org/10.3109/10715768709065292

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free