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Role of the innate immune system in the pathogenesis of multiple sclerosis

by Roopali Gandhi, Alice Laroni, Howard L Weiner
Journal of Neuroimmunology

Abstract

Multiple sclerosis {(MS)} is a chronic inflammatory autoimmune disease with heterogeneous clinical presentations and course. {MS} is considered to be a T cell mediated disease but in recent years contribution of innate immune cells in mediating {MS} pathogenesis is being appreciated. In this review, we have discussed the role of various innate immune cells in mediating {MS.} In particular, we have provided an overview of potential anti-inflammatory or pro-inflammatory function of {DCs,} microglial Cells, {NK} cells, {NK-T} cells and gamma delta T cells along with their interaction among themselves and with myelin. Given the understanding of the role of the innate immune cells in {MS,} it is possible that immunotherapeutic intervention targeting these cells may provide a better and effective treatment.

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