SCN1A rs3812718 polymorphism and susceptibility to epilepsy with febrile seizures: A meta-analysis

Abstract

Background: Evidence showed that the SCN1A IVS5N+5G>A polymorphism might be associated with susceptibility to epilepsy with febrile seizures (EFS), however, the published data were inconclusive. Therefore, a meta-analysis was performed to estimate the overall EFS risk with the polymorphism. Methods: The PubMed and Medline were searched up to March, 2013 for studies on the association between SCN1A IVS5N+5G>A polymorphism and EFS risk. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by means of a genetic model free approach. The heterogeneity and sensitivity of each report and the publication bias were also performed. All the statistical analyses were done using the STATA 11.0 software. Result: A total of 6 studies with 2719 cases and 2317 controls met the selection criteria. We found significant association between SCN1A polymorphism and EFS (A vs. G: OR. = 1.498, 95%CI. = 1.138-1.972; AA vs. GG: OR. = 2.292, 95%CI. = 1.620-3.243; AG vs. GG: OR. = 1.414, 95%CI. = 1.010-1.978; recessive model: OR. = 1.747, 95%CI. = 1.119-2.728 and dominant model: OR. = 1.730, 95%CI. = 1.259-2.376). When compared with the epilepsy without febrile seizure (EWFS), the subgroup analysis stratified by ethnicity showed that the SNP was significantly associated with EFS in Caucasian (A vs. G: OR. = 1.505, 95%CI. = 1.218-1.861; AA vs. GG: OR. = 2.081, 95%CI. = 1.358-3.189; recessive model: OR. = 1.715, 95%CI. = 1.273-2.310 and dominant model: OR. = 1.625, 95%CI. = 1.096-2.410), but not in Indian and Chinese. When applying Bonferroni correction (significance was set at 0.05/20), the Caucasian still has robust association with EFS and epilepsy. Conclusion: The present meta-analysis suggests that SCN1A IVS5N+5G>A polymorphism is a risk factor of EFS and epilepsy, especially in Caucasian. © 2013 Elsevier B.V.