Introduction: Serotonin has been extensively studied in relation to both personality features and suicidal behaviours. Objective: In this study, we considered the association between the serotonin receptor 1A (HTR1A) and 2C (HTR2C) SNPs and personality traits, as measured by the Temperament and Character Inventory (TCI), in a sample of suicide patients and healthy volunteers. Methods: The SNPs considered were, for HTR1A rs1423691, rs878567 and rs6295, and for HTR2C rs547536, rs2192372, rs6318, rs2428707, rs4272555 and rs1801412. The sample was composed of three groups: two German samples, consisting of a healthy control group of 289 subjects (42.6% males, mean age: 45.2 ± 14.9) and a psychiatric patient group of 111 suicide attempters (38.7% males, mean age: 39.2 ± 13.6), and an Italian sample, composed of 64 mood disorder patients (35.9% males, mean age: 43.0 ± 14.8). In the German samples all the SNPs were investigated, while in the Italian sample only the HTR1A rs6295 and the HTR2C rs6318 SNPs were considered. Results: Controlling for sex, age and educational level, single markers and haplotypes were not or only marginally associated with personality dimensions. Conclusions: Our study does not support the role of HTR1A and HTR2C gene variants on personality traits in both healthy volunteers and mood disorder patients. © 2008 Elsevier Ltd. All rights reserved.
CITATION STYLE
Serretti, A., Calati, R., Giegling, I., Hartmann, A. M., Möller, H. J., & Rujescu, D. (2009). Serotonin receptor HTR1A and HTR2C variants and personality traits in suicide attempters and controls. Journal of Psychiatric Research, 43(5), 519–525. https://doi.org/10.1016/j.jpsychires.2008.06.005
Mendeley helps you to discover research relevant for your work.