The analgesic response was evaluated by the tail immersion test in adult male (N = 30), female (N = 21) and androgenized female Wistar rats (N = 15). The reaction time for tail withdrawal from the hot water bath was faster for male than for female rats (3.48 ± 0.12 vs 6.46 ± 0.42 s). The reaction time of androgenized female rats was similar to that of male rats (3.08 ± 0.16 s). Blockade of opiate receptors with naloxone (2 mg/kg, ip) decreased the sensitivity to the noxious stimuli in males (4.08 ± 0.10 s) and in androgenized females (3.69 ± 0.19 s) but increased it in female rats (5.01 ± 0.41 s). These data show sex-related differences in the analgesic response evaluated by the tail immersion test and indicate that administration of androgens to newborn female rats affects their pain sensitivity.
CITATION STYLE
Molina, N., Bedran-De-Castro, M. T. B., & Bedran-De-Castro, J. C. (1994). Sex-related differences in the analgesic response to the rat tail immersion test. Brazilian Journal of Medical and Biological Research, 27(7), 1669–1672.
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