We previously reported an association between the SH2D2A gene encoding TSAd and multiple sclerosis (MS). Here a total of 2128 Nordic MS patients and 2004 controls were genotyped for the SH2D2A promoter GA repeat polymorphism and rs926103 encoding a serine to asparagine substitution at amino acid position 52 in TSAd. The GA16-rs926103*A haplotype was associated with MS in Norwegians (OR 1.4, P = 0.04). A similar trend was observed among Danes. In the independent Norwegian, Danish and Swedish sample sets the GA16 allele showed a combined OR of 1.13, P = 0.05. Thus, the present study shows that the SH2D2A gene may contribute to susceptibility to MS. © 2008 Elsevier B.V. All rights reserved.
CITATION STYLE
Lorentzen, Å. R., Smestad, C., Lie, B. A., Oturai, A. B., Åkesson, E., Saarela, J., … Harbo, H. F. (2008). The SH2D2A gene and susceptibility to multiple sclerosis. Journal of Neuroimmunology, 197(2), 152–158. https://doi.org/10.1016/j.jneuroim.2008.04.037
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