Single nucleotide polymorphisms and mRNA expression for melatonin MT2 receptor in depression

Abstract

Polymorphisms (rs 4753426 and rs 794837) and expression of the melatonin MT2 receptor gene were evaluated in 181 patients with recurrent depressive disorder (rDD) and 149 healthy subjects of Polish origin. We found an increased risk for rDD in patients with the C allele and a decreased risk in patients with the T allele (rs4753426). Patients with the AT heterozygote (rs794837) had an increased mRNA level. The significance of the MT2 receptor gene and the risk of rDD are suggested. © 2011 Elsevier Ltd.