Small protein-mediated quorum sensing in a Gram-negative bacterium

30Citations
Citations of this article
103Readers
Mendeley users who have this article in their library.

Abstract

The rice XA21 pattern recognition receptor binds a type I secreted sulfated peptide, called axY S22, derived from the Ax21 (activator of XA21-mediated immunity) protein. The conservation of Ax21 in all sequenced Xanthomonas spp. and closely related genera suggests that Ax21 serves a key biological function. Here we show that the predicted N-terminal sequence of Ax21 is cleaved prior to secretion outside the cell and that mature Ax21 serves as a quorum sensing (QS) factor in Xanthomonas oryzae pv. oryzae. Ax21-mediated QS controls motility, biofilm formation and virulence. We provide genetic evidence that the Xoo RaxH histidine kinase serves as the bacterial receptor for Ax21. This work establishes a critical role for small protein-mediated QS in a Gram-negative bacterium. © 2011 Han et al.

Cite

CITATION STYLE

APA

Han, S. W., Sriariyanun, M., Lee, S. W., Sharma, M., Bahar, O., Bower, Z., & Ronald, P. C. (2011). Small protein-mediated quorum sensing in a Gram-negative bacterium. PLoS ONE, 6(12). https://doi.org/10.1371/journal.pone.0029192

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free