Studies on liver-toxicity in rhigoma of Dioscorea bulbifera
Zhongguo Zhong yao za zhi Zhongguo zhongyao zazhi China journal of Chinese materia medica (2003)
- PubMed: 15139116
Available from www.ncbi.nlm.nih.gov
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Abstract
OBJECTIVE: To explore the liver-toxic fraction in Rhigoma of Dioscorea bulbifera. METHOD: The rats were randomized into four groups: control group (20% PVP-water), T001(10% total methanol extraction), F002(5% chloroform fraction) and F003(5% methanol fraction). Direct bilirubin (DBil) and Glutamic-pyruvic transaminase (GPT) were examined, and liver index was measured. The histological and morphological observations were performed with optical and electrical microscope. RESULT: T001 and F002 showed significant liver toxicity. CONCLUSION: The chloroform fraction was the liver-toxic fraction of D. bulbifera.
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