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Studies on liver-toxicity in rhigoma of Dioscorea bulbifera

by Xing-qi Tan, Jin-lan Ruan, Hai-sheng Chen, Ju-ying Wang
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica ()

Abstract

OBJECTIVE: To explore the liver-toxic fraction in Rhigoma of Dioscorea bulbifera. METHOD: The rats were randomized into four groups: control group (20% PVP-water), T001(10% total methanol extraction), F002(5% chloroform fraction) and F003(5% methanol fraction). Direct bilirubin (DBil) and Glutamic-pyruvic transaminase (GPT) were examined, and liver index was measured. The histological and morphological observations were performed with optical and electrical microscope. RESULT: T001 and F002 showed significant liver toxicity. CONCLUSION: The chloroform fraction was the liver-toxic fraction of D. bulbifera.

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