Background: Perilipins are proteins localized at the surface of the lipid droplet in adipocytes, steroid-producing cells and ruptured atherosclerotic plaques playing a role in the regulation of triglyceride deposition and mobilization. We investigated whether perilipin gene polymorphisms were associated with obesity, type 2 diabetes, and their related variables (anthropometric variables, plasma leptin, lipids, glucose and insulin concentrations) in a cross-sectional random sample of 1120 French men and women aged 35 to 65 years old, including 227 obese (BMI ≥ 30 kg/m2) and 275 type 2 diabetes subjects. Results: Among 7 perilipin polymorphisms tested, only 2 (rs4578621 and rs894160) of them were frequent enough to be fully investigated and we genotyped the sample using the PCR-RFLP method. No significant associations could be found between any of these polymorphisms and the studied phenotypes. Conclusion: The rs4578621 and rs894160 polymorphisms of the perilipin gene are not major genetic determinants of obesity and type 2 diabetes-related phenotypes in a random sample of French men and women. © 2006 Meirhaeghe et al; licensee BioMed Central Ltd.
CITATION STYLE
Meirhaeghe, A., Thomas, S., Ancot, F., Cottel, D., Arveiler, D., Ferrières, J., & Amouyel, P. (2006). Study of the impact of perilipin polymorphisms in a French population. Journal of Negative Results in BioMedicine, 5. https://doi.org/10.1186/1477-5751-5-10
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