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A study of the relationship between ameloblastoma and human papilloma virus.

by Abbas Khodayari Namin, Talat Mokhtari Azad, Behnam Eslami, Farzin Sarkarat, Mahmood Shahrokhi, Farzaneh Kashanian
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons ()


PURPOSE: The purpose of this study was to determine the relation of ameloblastoma with one of its probable etiologic factors, human papilloma virus (HPV). MATERIALS AND METHODS: This study was carried out in a retrospective, observational, and blind manner with information forms using an exact polymerize chain reaction. Fifty paraffinated blocks of ameloblastoma tumor were compared with 50 impacted third molar follicles. RESULTS: The results indicate that statistically the incidence of HPV positivity in the case group is significantly higher than that in the control group (P <.025). Furthermore, in determination of trace HPV type in HPV-positive samples, the incidence of type 6 HPV in the case group is significantly higher than that in the control group (P <.005). None of types 8, 11, 16, 18, 31, and 33 were observed. CONCLUSION: The results of this research conclude that HPV could be regarded as a possible etiologic factor of ameloblastoma.

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