[Study on the relationship between polymorphism of adiponectin gene and risk of ischemic stroke among Han population in the Northern parts of China].

Abstract

To explore the association between polymorphisms of adiponectin gene and the risk of ischemic stroke in Han population from the Northern parts of China. TaqMan probe of RT-PCR was applied to detect the genotype frequency of single nucleotide polymorphism (SNPs) (rs266729 and rs2241766) of adiponectin gene in 357 ischemic stroke cases who developed the episode at first time and with 345 healthy controls. Logistic regression analysis was used to evaluate the relationship of each genotype of SNPs and ischemic stroke. Mutation of rs2241766 (T > G) increased the risk of ischemic stroke among all the samples (OR = 1.55, P = 0.01) and it was still the risk factor of ischemic stroke when analyzed by multi-factors logistic regression after each factor was adjusted (OR = 1.55, P = 0.00). The polymorphism of rs266729 was not related to the risk of ischemic stroke among all the samples (OR = 1.13, P = 0.57). However, the genotype GG of rs266729 increased the risk of ischemic stroke among female population (OR = 3.25, P = 0.04). The variance of rs2241766 in adiponectin gene was related to the risk of ischemic stroke in Han population from the Northern parts of China and the genotype GG of rs266729 could possibly increase the risk of ischemic stroke in women of Han population from the Northern parts of the country.