HLA and other genetic variants, playing an important role in innate and adaptive immunity, are known to influence tuberculosis (TB) development in HIV-1-positive (HIV+) patients. Because inflammasome genes contribute to HIV-1 susceptibility, we investigated the possible association between polymorphisms in inflammasome genes with HIV-1 and Mycobacterium tuberculosis coinfection (HIV+TB+) in a case/control cohort of Brazilian individuals. Nineteen single-nucleotide polymoprhims in 8 inflammasome genes (NLRP1, NLRP3, AIM2, CARD8, CASP1, IL1B, IL1R, and HSP90) were analyzed in HIV+TB+ Brazilian patients (from Recife, Pernambuco). CARD8 rs6509365 polymorphism was associated with HIV+TB+ (P = 5 × 10-5), suggesting a predisposing role of this variant in M. tuberculosis susceptibility in HIV+ subjects (odds ratio = 2.45). This effect is even strong when this allele is combined to CARD8 rs2043211 single-nucleotide polymoprhim. The results of this study support the novel association between CARD8 gene and HIV+TB+ coinfection, demonstrating that inflammasome genetics could influence HIV-1 infection and the development of opportunistic infection. Copyright © 2013 by Lippincott Williams & Wilkins.
CITATION STYLE
Pontillo, A., Carvalho, M. S., Kamada, A. J., Moura, R., Schindler, H. C., Duarte, A. J. S., & Crovella, S. (2013). Susceptibility to mycobacterium tuberculosis infection in HIV-positive patients is associated with CARD8 genetic variant. Journal of Acquired Immune Deficiency Syndromes, 63(2), 147–151. https://doi.org/10.1097/QAI.0b013e31828f93bb
Mendeley helps you to discover research relevant for your work.