Horner-Emmons fluoroolefination of an aryl aldehyde followed by introduction of a second fluorine via "FBr" addition provides an original approach to the preparation of 1-alkyl-2-aryl-1,2-difluoroethenes. The utility of this procedure is demonstrated by the preparation of (E and Z)-α,β-difluorourocanic acid.
CITATION STYLE
Hajduch, J., Dolenský, B., Yoshida, S., Fan, J., & Kirk, K. L. (2008). Synthesis of (E)- and (Z)-α,β-difluorourocanic acid. Journal of Fluorine Chemistry, 129(2), 112–118. https://doi.org/10.1016/j.jfluchem.2007.09.006
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