Several neoclerodanes, such as salvinorin A (1) and herkinorin (3), have recently been shown to possess opioid receptor activity in vitro and in vivo. To explore the structure-affinity relationships of this interesting class of compounds, we have synthesized a series of analogues from 1 isolated from Salvia divinorum. Here, we report the semisynthesis of neoclerodane diterpenes and their structure-affinity relationships at opioid receptors. This work will allow the further development of novel opioid receptor ligands. © 2006 American Chemical Society and American Society of Pharmacognosy.
CITATION STYLE
Tidgewell, K., Harding, W. W., Lozama, A., Cobb, H., Shah, K., Kannan, P., … Prisinzano, T. E. (2006). Synthesis of salvinorin A analogues as opioid receptor probes. Journal of Natural Products, 69(6), 914–918. https://doi.org/10.1021/np060094b
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