Systematic confirmation study of reported prostate cancer risk-associated single nucleotide polymorphisms in Chinese men

Abstract

More than 30 prostate cancer (PCa) risk-associated loci have been identified in populations of European descent by genome-wide association studies. We hypothesized that a subset of these loci might be associated with PCa risk in Chinese men. To test this hypothesis, 33 single nucleotide polymorphisms (SNP), one each from the 33 independent PCa risk-associated loci reported in populations of European descent, were investigated for their associations with PCa risk in a case-control study of Chinese men (1108 cases and 1525 controls). We found that 11 of the 33 SNP were significantly associated with PCa risk in Chinese men (P<0.05). The reported risk alleles were associated with increased risk for PCa, with allelic odds ratios ranging from 1.12 to 1.44. The most significant locus was located on 8q24 region 2 (rs16901979, P=5.14×10 -9) with a genome-wide significance (P<10 -8), and three loci reached the Bonferroni correction significance level (P<1.52×10 -3), including 8q24 region 1 (rs1447295, P=7.04×10 -6), 8q24 region 5 (rs10086908, P=9.24×10 -4) and 8p21 (rs1512268, P=9.39×10 -4). Our results suggest that a subset of the PCa risk-associated SNP discovered by genome-wide association studies among men of European descent is also associated with PCa risk in Chinese men. This finding provides evidence of ethnic differences and similarity in genetic susceptibility to PCa. Genome-wide association studies in Chinese men are needed to identify Chinese-specific PCa risk-associated SNP. © 2011 Japanese Cancer Association.